Diisopropyl Ether → HCID 18929757, compound

HRID 1598577Notes

Reaction equation

HRID 1598577 reaction equation
Br.C(O)(=O)C.[N:6]1[NH:7][C:8](=[O:32])[CH2:9][CH2:10][C:11]=1[C:12]1[S:16][C:15]2[CH2:17][CH2:18][CH:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[CH3:31])(=[O:24])=[O:23])[CH2:20][C:14]=2[CH:13]=1.C(OC(C)C)(C)C>CS(C)=O>[N:6]1[NH:7][C:8](=[O:32])[CH:9]=[CH:10][C:11]=1[C:12]1[S:16][C:15]2[CH2:17][CH2:18][CH:19]([NH:21][S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[CH3:31])(=[O:24])=[O:23])[CH2:20][C:14]=2[CH:13]=1

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 18929824HCID 18929824, compoundHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 18929757HCID 18929757, compoundYield 71.3%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In 8 ml of a 25% hydrogen bromide-acetic acid solution was suspended 1.41 g of 2-[4,5-dihydropyridazin-3(2H)-on-6-yl]-5-[(2-methylphenyl)sulfonylamino]-4,5,6,7-tetrahydrobenzo-[b]thiophene, and 0.25 ml of dimethylsulfoxide was added thereto. The mixture was stirred at room temperature for 2 hours. Then, diisopropyl ether was added to the reaction mixture, and crystals precipitated were collected by filtration to obtain 1.00 g of 2-[pyridazin-3(2H)-on-6-yl]-5-[(2-methylphenyl)sulfonylamino]-4,5,6,7-tetrahydrobenzo[b]thiophene.

Workup

  1. additionwas added
  2. customprecipitated
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-56700fefadb04a16a05cd5c562610cf8
Source dataset
uspto-grants-1998_04
Patent number
US05739132

Reaction notes

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