反应详情

In a flask is placed 5,8-dimethyl-6-nitro-4-quinolone (3.01 g, 13.8 mmol) with phosphorus oxychloride (41.3 g, 268 mmol). The mixture is refluxed under argon with stirring for 3 hours. After cooling to room temperature the mixture is poured on crushed ice, and concentrated ammonium hydroxide (100 mL) is added. Extraction with chloroform (2×200 mL), drying over potassium carbonate, filtration and solvent removal by rotary evaporation gives 4-chloro-5,8-dimethyl-6-nitroquinoline.

1. customIn a flask is placed
2. temperatureThe mixture is refluxed under argon
3. additionis poured
4. additionis added
5. extractionExtraction with chloroform (2×200 mL)
6. dry with materialdrying over potassium carbonate, filtration and solvent removal by rotary evaporation