Hydrogen Bromide → HCID 376124, compound

HRID 1598898Notes

Reaction equation

HRID 1598898 reaction equation
C(OC([NH:11][CH2:12][C:13]([NH:15][C:16]1[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=1[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19])=[O:14])=O)C1C=CC=CC=1.[BrH:30].CCOCC>C(O)(=O)C>[BrH:30].[NH2:11][CH2:12][C:13]([NH:15][C:16]1[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=1[C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])=[O:14]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 18930606HCID 18930606, compound

Product 1

HCID 376124HCID 376124, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of N-benzyloxycarbonyl derivative (2a, 3.13 g, 8.06 mmol) obtained in Preparation 1 and a solution of 30% hydrobromic acid in acetic acid is stirred for 1 hour. Excess ether is added, and the resultant precipitate is filtered off. After washing with ether, it is dried to obtain 2.50 g (92%) of hydrobromate (compound 3a).

Workup

  1. customobtained in Preparation 1
  2. filtrationthe resultant precipitate is filtered off
  3. washAfter washing with ether, it
  4. customis dried

Sources & evidence

ORD record
ord-6d57f4745829462e90f9b08758c91d70
Source dataset
uspto-grants-1998_04
Patent number
US05739162

Reaction notes

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