反应详情

To a mixture of tetrahydrofuran (400 ml) and ethylene glycol (60 ml) is added with stirring sodium hydride (60% dispersion, 3.38 g) under ice-cooling, and thereto is added 4,6-dichloro-5-(4-methylphenyl)pyrimidine (20.0 g). The mixture is stirred under ice-cooling for 30 minutes, and then stirred at room temperature for two hours. The mixture is weakly acidified with acetic acid, and concentrated under reduced pressure. The residue is dissolved in ethyl acetate, and washed, dried, and concentrated to dryness under reduced pressure. The residue is crystallized from hexane to give 2-{6-chloro-5-(4-methylphenyl)pyrimidin-4-yloxy}ethanol (21.85 g).

1. temperaturecooling
2. temperaturecooling for 30 minutes
3. stirringstirred at room temperature for two hours
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue is dissolved in ethyl acetate
6. washwashed
7. customdried
8. concentrationconcentrated to dryness under reduced pressure
9. customThe residue is crystallized from hexane