Hydrochloric Acid → HCID 18784789, compound

HRID 1599048Notes

Reaction equation

HRID 1599048 reaction equation
[F:1][C:2]([F:40])([F:39])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][NH:22][C:23]([N:25]2[CH2:30][CH2:29][CH:28]([NH:31][C:32](=O)[O:33]C(C)(C)C)[CH2:27][CH2:26]2)=[O:24])[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].Cl.O1[CH2:47][CH2:46]OCC1>C1COCC1>[C:32]([NH:31][CH:28]1[CH2:29][CH2:30][N:25]([C:23]([NH:22][CH2:21][CH2:20][C:7]2([C:5]([NH:4][CH2:3][C:2]([F:40])([F:39])[F:1])=[O:6])[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:13]3[C:8]2=[CH:9][CH:10]=[CH:11][CH:12]=3)=[O:24])[CH2:26][CH2:27]1)(=[O:33])[C:47]1[CH:46]=[CH:9][CH:8]=[CH:7][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 131720605HCID 131720605, compound

Product 1

HCID 18784789HCID 18784789, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of Example 487 compound (1.1 g, 1.97 mmol) in THF (4 mL) was added 4N HCl in dioxane (9 mL, 36.4 mmol). The reaction mixture was stirred at room temperature for 3 h and concentrated in vacuo and then from dioxane (3×10 mL) to give crude title compound (1.46 g) as a white foamy solid.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-73d104432e0a4ad492e4524ea5d71af0
Source dataset
uspto-grants-1998_04
Patent number
US05739135

Reaction notes

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