HRID1599153

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7397

p-Toluenesulfonyl chloride

C7H7ClO2S

结构：O=C(Cc1ccccc1N1CCCC1)N1CC2CC(CO)CC(O)(c3ccccc3F)C2C1

HCID86752420

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)OCC2CC3CN(C(=O)Cc4ccccc4N4CCCC4)CC3C(O)(c3ccccc3F)C2)cc1

HCID86752419

未命名化合物

收率 26.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

The procedure is as described for Example 13, starting from 0.2 g of (3aRS,4RS,6SR,7aSR)-6-hydroxymethyl-4-(2-fluorophenyl)-2-[2-(1-pyrrolidinyl)phenylacetyl]perhydroisoindol-4-ol, 0.168 g of p-toluenesulphonyl chloride and 0.124 cm3 of triethylamine, and gives 0.07 g of (3aRS,4RS,6SR,7aSR)-6-p-toluenesulphonyloxymethyl-4-(2-fluorophenyl)-2-[2-(1-pyrrolidinyl)phenylacetyl]perhydroisoindol-4-ol in the form of a thick white foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eedb23fb2fc24cb0a6de5046c40982df
来源数据集: uspto-grants-1998_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05739351
来源说明: uspto-grants-1998_04

反应 SMILES

[OH:1][CH2:2][CH:3]1[CH2:11][CH:10]2[CH:6]([CH2:7][N:8]([C:12](=[O:25])[CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[CH2:9]2)[C:5]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[F:33])([OH:26])[CH2:4]1.[C:34]1([CH3:44])[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1>C(N(CC)CC)C>[C:34]1([CH3:44])[CH:39]=[CH:38][C:37]([S:40]([O:1][CH2:2][CH:3]2[CH2:11][CH:10]3[CH:6]([CH2:7][N:8]([C:12](=[O:25])[CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[N:20]4[CH2:24][CH2:23][CH2:22][CH2:21]4)[CH2:9]3)[C:5]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[F:33])([OH:26])[CH2:4]2)(=[O:42])=[O:41])=[CH:36][CH:35]=1