HCID 18928141, compound → HCID 18928106, compound

HRID 1599421Notes

Reaction equation

HRID 1599421 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][N:25]1[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]1)=[O:5])C>Br>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:21])([F:22])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][N:25]1[CH2:26][CH2:27][N:28]([CH3:31])[CH2:29][CH2:30]1)([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 18928141HCID 18928141, compound

Product 1

HCID 18928106HCID 18928106, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A solution of 2-ethoxycarbonyl-1-(4-methyl-1-piperazinyl)methyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 11) (380 mg, 0.87 mmol) in hydrobromic acid (48% in water) (20 ml) was stirred at 80° C. for 30 h. The mixture was concentrated in vacuo and the residue stirred with ether. The product which was isolated by filtration was recrystallized from methanol/ether to afford 260 mg (57%) of the title compound as a HBr salt. M.p. >240° C.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe product which was isolated by filtration
  3. customwas recrystallized from methanol/ether

Sources & evidence

ORD record
ord-362ae0317fd7479992c56268cb8698ee
Source dataset
uspto-grants-1998_04
Patent number
US05741785

Reaction notes

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