HCID 18928135, compound → HCID 18928117, compound

HRID 1599434Notes

Reaction equation

HRID 1599434 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][P:25]([OH:28])([OH:27])=[O:26])=[O:5])C>Br>[C:4]([C:6]1[N:7]=[C:8]2[C:17](=[O:18])[NH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:19]([F:22])([F:20])[F:21])[CH:14]=3)[N:9]2[C:23]=1[CH2:24][P:25]([OH:27])([OH:28])=[O:26])([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 18928135HCID 18928135, compound

Product 1

HCID 18928117HCID 18928117, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

2-Ethoxycarbonyl-1-phosphonomethyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (example 30) (210 mg, 0.5 mmol) in hydrobromic acid (48% in water) (20 ml) was stirred at 80° C. for 16 h. The mixture was concentrated in vacuo and the residue stirred with ether. The product, which was isolated by filtration was washed with cold water to afford 190 mg (97%) of the title compound. M.p. >250° C.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customThe product, which was isolated by filtration
  3. washwas washed with cold water

Sources & evidence

ORD record
ord-3dd2905e1888449293be2df967645538
Source dataset
uspto-grants-1998_04
Patent number
US05741785

Reaction notes

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