Oxalyl chloride → 3-(4-Methylphenyl)propanoyl chloride
Reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH3:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14]CC(O)=O)=[CH:10][CH:9]=1>ClCCl>[CH3:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:1][C:2]([Cl:4])=[O:3])=[CH:10][CH:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 20 °C
Procedure
A solution of oxalyl chloride (5 ml) in dichloromethane (5 ml) was added dropwise to a solution of 3-(4-methylphenyl)propionic acid (1.5 g) in dichloromethane (20 ml). The mixture was stirred at 20° C. for 16 hours and then evaporated to give 3-(4-methylphenyl)propionyl chloride as an oil.
Workup
- customevaporated
Sources & evidence
- ORD record
- ord-8003302ee8fe4e75926472882c33d452
- Source dataset
- uspto-grants-1998_04
- Patent number
- US05741800
Reaction notes
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