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HRID1599922

反应详情

EQUATION

反应方程式

HRID 1599922 的结构方程式

REACTANTS

反应物

3
反应SMILES：CN(C)C=O
HCID6228

Dimethylformamide

C3H7NO

反应SMILES：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

反应SMILES：NCCOCc1ccc(C(=O)NC[C@H](NS(=O)(=O)c2ccccc2)C(=O)O)cc1
HCID15850751

未命名化合物

PRODUCTS

产物

1
反应SMILES：N=C(N)NCCOCc1ccc(C(=O)NC[C@H](NS(=O)(=O)c2ccccc2)C(=O)O)cc1
HCID178513013

未命名化合物

PROCEDURE

实验过程

Amine 15-5 (40 mg, 0.095 mmol), PCA·HCl (15 mg, 0.10 mmol), and DIPEA (35 mL, 0.20 mmol) were combined in 1 mL DMF and heated at 50° for 16 h. Concentration, and flash chromatography (silica, 20:1:1 EtOH/NH4OH/H2O) provided 15-6 as a white solid.

WORKUP

后处理

  1. temperatureheated at 50° for 16 h
  2. concentrationConcentration, and flash chromatography (silica, 20:1:1 EtOH/NH4OH/H2O)