Oxalyl chloride → HCID 53725594, compound

HRID 1599990Notes

Reaction equation

HRID 1599990 reaction equation
[C:1]([Cl:6])(=O)[C:2]([Cl:4])=[O:3].ClC(=[CH:12][C:13]1[CH:18]=[C:17]([C:19]2[C:23]([Cl:24])=[C:22]([O:25][CH:26]([F:28])[F:27])[N:21]([CH3:29])[N:20]=2)[C:16]([Cl:30])=[CH:15][C:14]=1[Cl:31])C(O)=O>CN(C)C=O.C1(C)C=CC=CC=1>[Cl:6][C:1](=[CH:12][C:13]1[CH:18]=[C:17]([C:19]2[C:23]([Cl:24])=[C:22]([O:25][CH:26]([F:27])[F:28])[N:21]([CH3:29])[N:20]=2)[C:16]([Cl:30])=[CH:15][C:14]=1[Cl:31])[C:2]([Cl:4])=[O:3]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 53728432HCID 53728432, compound

Product 1

HCID 53725594HCID 53725594, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolvent

Procedure

3 drops of dimethylformamide and then 11.1 g (87 mmol) of oxalyl chloride were added dropwise to a solution of 12.5 g (29 mmol) of 2-chloro-3-(2,4-dichloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)phenyl)propenoic acid in 300 ml of toluene. The reaction mixture was stirred at reflux temperature for 5 hours and then concentrated. Yield: quantitative.

Workup

  1. temperatureat reflux temperature for 5 hours
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-317a18a0dc9141d0b384dd6fa1ecd964
Source dataset
uspto-grants-1998_04
Patent number
US05744426

Reaction notes

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