Water → HCID 15908416, compound

HRID 1600008Notes

Reaction equation

HRID 1600008 reaction equation
[Cl:1][C:2]1[C:3](=[O:11])[N:4](C)[C:5](=[O:9])[NH:6][C:7]=1Cl.[CH3:12][N:13]=[C:14]=[S:15].O.[CH3:17][N:18](C)C=O>>[CH3:12][NH:13][C:14]([NH:18][CH2:17][C:7]1[NH:6][C:5](=[O:9])[NH:4][C:3](=[O:11])[C:2]=1[Cl:1])=[S:15]

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 11167Methyl isothiocyanateHCID 69944581HCID 69944581, compound

Product 1

HCID 15908416HCID 15908416, compoundYield 61%

Conditions

Temperature
70 °C

Procedure

A suspension of 0.50 g of 5-chloro-6-chloro-methyluracil and 0.22 g of methyl isothiocyanate in N,N-dimethylformamide (3 ml) was heated at 70° C. for 4 hours under stirring. Water (50 ml) was added to the reaction mixture. A crystallized matter was collected by filtration and then washed with water and methanol, whereby 435 mg of the title compound were obtained (yield: 61%).

Workup

  1. filtrationA crystallized matter was collected by filtration
  2. washwashed with water and methanol

Sources & evidence

ORD record
ord-b426eab68d5746e299e5f2f1ac2935a2
Source dataset
uspto-grants-1998_04
Patent number
US05744475

Reaction notes

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