Acetonitrile → Diisopropylethylamine

HRID 1600118Notes

Reaction equation

HRID 1600118 reaction equation
N(C[C@@H]1O[CH2:9][C@H:7](S)[CH2:6]1)=[N+]=[N-].C(OC(=O)C)C.CCC[CH2:20][CH2:21][CH3:22].[C:23](#[N:25])[CH3:24]>>[CH3:24][CH2:23][N:25]([CH:7]([CH3:6])[CH3:9])[CH:21]([CH3:20])[CH3:22]

Participants

4

Reactant 3

HCID 6342Acetonitrile2×HCID 21226206Ethyl acetate hexaneHCID 22869819HCID 22869819, compound

Product 1

HCID 81531Diisopropylethylamine

Procedure

The title compound is prepared by the procedure of Example 17 using 0.441 gof product from Example 118 in 10 ml of acetonitrile, 1.8 g of product fromExample 15 in 10 ml of acetonitrile and 0.41 ml of Hunig's base to give 0.747 g of the desired product after chromatography (silica gel: 75% ethylacetate/hexane). IR(KBr): 2101, 1769 and 1708 cm-1.

Sources & evidence

ORD record
ord-ab56ba29d40b483da136cd9acdd9c1d3
Source dataset
uspto-grants-1998_04
Patent number
US05744465

Reaction notes

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