Dichloromethane → HCID 57016003, compound

HRID 1600120Notes

Reaction equation

HRID 1600120 reaction equation
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:3].CC[N:17]([CH:21]([CH3:23])C)[CH:18]([CH3:20])C.C(Cl)Cl.[O:27]1C[CH2:30][CH2:29][CH2:28]1.C(OCC)(=[O:34])C.CCCCCC>>[N+:12]([C:9]1[CH:10]=[CH:11][C:6]([CH2:5][O:4][C:2](=[O:3])[N:17]([CH2:18][CH3:20])[CH2:21][CH:23]2[CH2:30][CH:29]([OH:34])[CH2:28][O:27]2)=[CH:7][CH:8]=1)([O-:14])=[O:13]

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 782054-Nitrobenzyl chloroformateHCID 81531DiisopropylethylamineHCID 21226206Ethyl acetate hexane

Product 1

HCID 57016003HCID 57016003, compound

Procedure

The title compound is prepared by the procedure of Example 124 using 4.6 g of product from Example 130, 4.73 g of 4-nitrobenzyl chloroformate, 2.7 mlof Hunig's base, 25 ml of methylene chloride and 7 ml of tetrahydrofuran togive 2,035 g of the desired product after chromatography (silica gel: 75% ethyl acetate/hexane).

Sources & evidence

ORD record
ord-56717d4c4f5f4fb28ba858d507c27a48
Source dataset
uspto-grants-1998_04
Patent number
US05744465

Reaction notes

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