反应详情

A solution of 11 g of [R-(R*,R*)]-2,2-dimethyl-alpha-2-propenyl-1,3-dioxolane-4-methanol, prepared by the procedure described in J. Am. Chem. Soc., 1985, 107(26), 8186-8190, in 300 ml of 1:1 tetrahydrofuran: 2N hydrochloric acid is heated at the reflux temperature of the solvents for 2 hours. Chloroform is added and the layers are separated. The aqueous layer is re-extracted 2X with chloroform. The aqueous layer is neutralized with potassium carbonate and exhaustively extracted with 80% chloroform/iso-propanol. Thecombined organic layers are concentrated in vacuo to give 7.51 g of the desired product.

1. customthe layers are separated
2. extractionThe aqueous layer is re-extracted 2X with chloroform
3. extractionexhaustively extracted with 80% chloroform/iso-propanol
4. concentrationThecombined organic layers are concentrated in vacuo