Tetrahydrofuran → HCID 12336001, compound

HRID 1600161Notes

Reaction equation

HRID 1600161 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][S:8][CH:7]([S:11]C(=O)C)[CH2:6]2)[O:4][CH2:3][CH2:2]1.C[O-].[Na+].O1CCCC1.OP([O-])(O)=O.[K+]>C(OCC)(=O)C>[O:1]1[C:5]2([CH2:10][CH2:9][S:8][CH:7]([SH:11])[CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 516951Monobasic potassium phosphateHCID 10942334Sodium MethoxideHCID 53909053HCID 53909053, compound

Product 1

HCID 12336001HCID 12336001, compoundYield 80.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 0.56 g of product from Example 395, 0.60 ml of 4.37M sodium methoxide and 10 ml of tetrahydrofuran is stirred in an ice bath for 20 minutes. Ethyl acetate is added followed by 0.5M potassium phosphate monobasic. The organic layer is dried and concentrated in vacuo to give 0.37 g of the desired product as a yellow oil.

Workup

  1. customThe organic layer is dried
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cb8e8d097a584aaeab6f7be2be3dfaae
Source dataset
uspto-grants-1998_04
Patent number
US05744465

Reaction notes

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