Imidazole → HCID 18926605, compound

HRID 1600166Notes

Reaction equation

HRID 1600166 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][N:12]([CH3:14])[CH3:13])=[CH:8][C:7]([N+:15]([O-:17])=[O:16])=[CH:6][CH:5]=2.[NH:18]1C=CN=[CH:19]1>C1(C)C(C)=CC=CC=1>[N:12]1([CH2:11][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([N+:15]([O-:17])=[O:16])[CH:8]=3)[NH:3][C:2]=2[CH3:1])[CH:13]=[CH:19][N:18]=[CH:14]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 280316N,N-Dimethyl-1-(2-methyl-5-nitro-1H-indol-3-yl)methanamine

Product 1

HCID 18926605HCID 18926605, compoundYield 89.4%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Treatment of 2, N,N-trimethyl-5-nitro-1H-indole-3-methanamine (J.Org.Chem.,28,2921(1963)) (5.60 g) with imidazole (1.90 g) in xylene (100 ml) according to the method of Preparation 1 gave the title compound (5.50 g),m.p. 240°-242° C. Found: C,61.02; H,4.41; N,21.68. C13 H12N4O2 requires: C,60.92; H,4.72; N,21.87%.

Sources & evidence

ORD record
ord-d93916c46aef4da4bb5ce4f36aee5c77
Source dataset
uspto-grants-1998_04
Patent number
US05744488

Reaction notes

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