Ammonium formate → HCID 18926515, compound

HRID 1600186Notes

Reaction equation

HRID 1600186 reaction equation
[CH3:1][O:2][C:3]([CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[C:11](/[CH:16]=[CH:17]/[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:8]1)=[O:4].C([O-])=O.[NH4+]>[Pd]>[CH3:1][O:2][C:3]([CH2:5][CH2:6][N:7]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:10]=2[C:9]([CH2:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)=[CH:8]1)=[O:4]

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 86752489HCID 86752489, compound

Product 1

HCID 18926515HCID 18926515, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Treatment of t-butyl (E)-3-[1-(2-methoxycarbonylethyl)-3-(3-pyridylmethyl)-1H-indole-4-yl]-2-propenoate (5.15 g) with 10% palladium on carbon (0.50 g) and ammonium formate (7.71 g) according to the method of Preparation 23 gave the title compound, (4.67 g) m.p. 80°-82° C. Found: C,71.43; H,7.06; N,6.35. C25H30N2O4 requires: C,71.06; H,7.16; N,6.63%.

Sources & evidence

ORD record
ord-fef2ecb9e9f24eb785afb905bb9f56e2
Source dataset
uspto-grants-1998_04
Patent number
US05744488

Reaction notes

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