Potassium Carbonate → HCID 22292062, compound

HRID 1600196Notes

Reaction equation

HRID 1600196 reaction equation
[NH2:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].[CH2:17]([Cl:20])[C:18]#[CH:19]>C(#N)C>[ClH:20].[CH2:19]([NH:1][CH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1)[C:18]#[CH:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 122213-Chloro-1-propyneHCID 123445(+-)-1-Aminoindan

Product 1

HCID 22292062HCID 22292062, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
60 °C

Procedure

10.0 g of racemic 1-aminoindan and 10.4 g of potassium carbonate were addedto 75 ml of acetonitrile. The resulting suspension was heated to 60°C. and 4.5 g of propargyl chloride was added dropwise.

Sources & evidence

ORD record
ord-81703e38e2dc469e85e913f93edb19c5
Source dataset
uspto-grants-1998_04
Patent number
US05744500

Reaction notes

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