Azobisisobutyronitrile → 5-(Bromomethyl)-2-phenylpyrimidine

HRID 1600569ノート

反応式

HRID 1600569 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][CH:7]=1.[Br:14]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Br:14][CH2:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 8174325-Methyl-2-phenylpyrimidine

生成物 1

HCID 218300465-(Bromomethyl)-2-phenylpyrimidine

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A suspension of 5-methyl-2-phenyl-pyrimidine (3.0 g, 17.6 mmol), N-bromosuccinimide (2.0 g, 11.2 mmol) and a,a'-azobis(isobutyronitrile) (0.10 g, 0.61 mmol) in dry carbon tetrachloride (150 mL) is refluxed for 0.5 hours. After cooling to room temperature, the mixture is filtered and the filtrate is concentrated in vacuo, giving 5-bromomethyl-2-phenyl-pyrimidine as an orange oil.

後処理

  1. temperatureis refluxed for 0.5 hours
  2. filtrationthe mixture is filtered
  3. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-0b0126c669cc43eb9621cc70f65d9757
出典データセット
uspto-grants-1999_11
特許番号
US05977075

反応ノート

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