反应详情

温度

100 °C

148 g of 4-hydroxy-6-methylthiopyrimido[5,4-d]pyrimidine, 286 ml of hexamethyldisilazane, 333 g of 3-chloro-4-fluoroaniline and 15 g of p-toluenesulphonic acid are heated at 140° C. for 23 hours. The reaction mixture is cooled and, after addition of 4 1 of methanol, heated at 100° C. for one hour. The methanol is distilled off and the residue is triturated three times with diethyl ether and filtered off with suction.

1. temperatureThe reaction mixture is cooled
2. distillationThe methanol is distilled off
3. customthe residue is triturated three times with diethyl ether
4. filtrationfiltered off with suction