Hydrochloric Acid → HCID 18394400, compound

HRID 1601034Notes

Reaction equation

HRID 1601034 reaction equation
C([N:8]1[C@H:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:13][CH:14]=2)[CH2:9]1)(OC(C)(C)C)=O.[ClH:29]>CCOC(C)=O>[ClH:29].[C:18]([C@@H:17]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:13][CH:14]=2)[CH2:9][NH:8]1)([O:20][CH2:21][CH3:22])=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18394396HCID 18394396, compound

Product 1

HCID 18394400HCID 18394400, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The Boc-amine from Step 3 (48 mg) was deprotected using 75 mL EtOAc saturated with HCl. Removal of the solvent in vacuo gave the title compound as a white solid.

Workup

  1. customRemoval of the solvent in vacuo

Sources & evidence

ORD record
ord-b929ea0d0864441a9e6c89a993baec13
Source dataset
uspto-grants-1999_11
Patent number
US05977134

Reaction notes

Loading…