Tetrahydrofuran → 3,3-Bis(4-fluorophenyl)propanol

HRID 160142Notes

Reaction equation

HRID 160142 reaction equation
[Al+3:23].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][C:10](=[O:11])[O:12][CH2:13][CH3:14])[c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[cH:6][cH:7]1.[H-:22].[H-:25].[H-:26].[H-:27].[Li+:24]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][CH2:10][OH:11])[c:15]2[cH:16][cH:17][c:18]([F:21])[cH:19][cH:20]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 23522917Ethyl 3,3-bis(4-fluorophenyl)propanoate

Product 1

HCID 197832883,3-Bis(4-fluorophenyl)propanol

Sources & evidence

ORD record
ord-897a2f023a9f49d7a3afe8df3ecd911b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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