Tetrahydrofuran → HCID 21832296, compound

HRID 1601752Notes

Reaction equation

HRID 1601752 reaction equation
O1CCCC1.[CH3:6][C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9](Cl)=[O:10].[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:28]=[CH:27][C:22]([O:23][CH2:24][CH2:25][NH2:26])=[CH:21][CH:20]=1>C(N(CC)CC)C>[F:16][C:17]([F:29])([F:30])[O:18][C:19]1[CH:28]=[CH:27][C:22]([O:23][CH2:24][CH2:25][NH:26][C:9](=[O:10])[C:8]2[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=2[CH3:6])=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 8028Tetrahydrofuran2×HCID 702762-Methylbenzoyl chlorideHCID 11746174HCID 11746174, compound

Product 1

HCID 21832296HCID 21832296, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A tetrahydrofuran (5 ml) solution of 2-methylbenzoyl chloride (0.77 g) was added dropwise under ice-cooling and stirring to a tetrahydrofuran (20 ml) solution of 2-(4-trifluoromethoxyphenoxy)ethylamine (1.10 g) and triethylamine (0.51 g) and the mixture was further stirred at room temperature for one hour.

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-cfb74bd3b0744bc294133774e9ca335c
Source dataset
uspto-grants-1999_11
Patent number
US05977410

Reaction notes

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