Tetrahydrofuran → HCID 21832295, compound

HRID 1601754Notes

Reaction equation

HRID 1601754 reaction equation
O1CCCC1.[F:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:8]=1[C:9](Cl)=[O:10].[F:17][C:18]([F:32])([F:31])[CH2:19][O:20][C:21]1[CH:30]=[CH:29][C:24]([O:25][CH2:26][CH2:27][NH2:28])=[CH:23][CH:22]=1>C(N(CC)CC)C>[F:17][C:18]([F:31])([F:32])[CH2:19][O:20][C:21]1[CH:30]=[CH:29][C:24]([O:25][CH2:26][CH2:27][NH:28][C:9](=[O:10])[C:8]2[C:7]([F:6])=[CH:15][CH:14]=[CH:13][C:12]=2[F:16])=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 8028Tetrahydrofuran2×HCID 874382,6-Difluorobenzoyl chlorideHCID 21832290HCID 21832290, compound

Product 1

HCID 21832295HCID 21832295, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A tetrahydrofuran (5 ml) solution of 2,6-difluorobenzoyl chloride (0.70 g) was added dropwise under ice-cooling and stirring to a tetrahydrofuran (20 ml) solution of 2-[4-(2,2,2-trifluoroethoxy)phenoxy]ethylamine (0.94 g) and triethylamine (0.40 g) and the mixture was further stirred at room temperature for one hour.

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-d7f00366bf2f480c9fea7dc07e5f09ee
Source dataset
uspto-grants-1999_11
Patent number
US05977410

Reaction notes

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