HRID1601919

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：CS(=O)(=O)OCCC1(c2ccc(Cl)c(Cl)c2)CN(Cc2ccccc2)C(=O)CO1

HCID19591389

未命名化合物

结构：CN(C)c1nc(C2(c3ccccc3)CCNCC2)cs1.Cc1ccc(S(=O)(=O)O)cc1

HCID21200554

未命名化合物

PRODUCTS

生成物

结构：CN(C)c1nc(C2(c3ccccc3)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CN(Cc4ccccc4)C(=O)CO3)CC2)cs1.Cl.Cl

HCID21200598

未命名化合物

收率 131.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

This compound is prepared by the procedure described in EXAMPLE 41 from 1.1 g of the compound obtained in step B of EXAMPLE 14, 1.3 g of 4-[2-(dimethylamino)thiazol-4-yl]-4-phenylpiperidine p-toluenesulfonate, 0.97 g of K2CO3 and 4 ml of DMF to give 0.76 g of the expected product. M.p.=155-160° C.

WORKUP

后处理

customThis compound is prepared by the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-80dd837c15054315bb0558999fbbbea6
来源数据集: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05977359
来源说明: uspto-grants-1999_11

反应 SMILES

[CH2:1]([N:8]1[CH2:13][C:12]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)([CH2:14][CH2:15]OS(C)(=O)=O)[O:11][CH2:10][C:9]1=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH3:41][N:42]([CH3:60])[C:43]1[S:44][CH:45]=[C:46]([C:48]2([C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[N:47]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:27].[ClH:27].[CH2:1]([N:8]1[CH2:13][C:12]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[C:23]([Cl:28])[CH:22]=2)([CH2:14][CH2:15][N:51]2[CH2:50][CH2:49][C:48]([C:46]3[N:47]=[C:43]([N:42]([CH3:60])[CH3:41])[S:44][CH:45]=3)([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:53][CH2:52]2)[O:11][CH2:10][C:9]1=[O:29])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1