HRID1601922

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：O=C(NC1(c2ccccc2)CCNCC1)N1CCCC1.O=S(=O)(O)c1ccccc1

HCID21200475

未命名化合物

结构：CN(C)C(=O)NC1(c2ccccc2)CCN(CCC2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1.CN(C)C(=O)NC1(c2ccccc2)CCN(CCC2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1.Cl.Cl.O

HCID131720058

未命名化合物

PRODUCTS

生成物

结构：Cl.O.O=C(NC1(c2ccccc2)CCN(CCC2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1)N1CCCC1

HCID21200640

未命名化合物

收率 47.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

This compound is prepared by the procedure described in EXAMPLE 45 from 1.2 g of the compound obtained in step C of EXAMPLE 37, 1.4 g of 4-phenyl-4-(pyrrolidin-1-ylcarbonylamino)piperidine benzenesulfonate, 1.2 g of K2CO3 and 2 ml of DMF to give 0.3 g of the expected product. M.p.=163-168° C.

WORKUP

后处理

customThis compound is prepared by the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af7df4b1a8294159b64adb902df1be42
来源数据集: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05977359
来源说明: uspto-grants-1999_11

反应 SMILES

O.[ClH:2].[C:3](N1CCOC(C2C=CC(F)=C(F)C=2)(CCN2CCC(NC(N(C)C)=O)(C3C=CC=CC=3)CC2)C1)(=[O:10])[C:4]1C=CC=CC=1.[C:45]([N:53]1[CH2:58][CH2:57][O:56][C:55]([CH2:67][CH2:68][N:69]2[CH2:74][CH2:73][C:72]([C:81]3[CH:86]=[CH:85][CH:84]=[CH:83][CH:82]=3)([NH:75][C:76]([N:78]([CH3:80])[CH3:79])=[O:77])[CH2:71][CH2:70]2)([C:59]2[CH:64]=[CH:63][C:62]([F:65])=[C:61]([F:66])[CH:60]=2)[CH2:54]1)(=[O:52])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1.Cl.C1(S(O)(=O)=O)C=CC=CC=1.C1(C2(NC(N3CCCC3)=O)CCNCC2)C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[OH2:10].[ClH:2].[C:45]([N:53]1[CH2:58][CH2:57][O:56][C:55]([C:59]2[CH:64]=[CH:63][C:62]([F:65])=[C:61]([F:66])[CH:60]=2)([CH2:67][CH2:68][N:69]2[CH2:74][CH2:73][C:72]([C:81]3[CH:82]=[CH:83][CH:84]=[CH:85][CH:86]=3)([NH:75][C:76]([N:78]3[CH2:80][CH2:4][CH2:3][CH2:79]3)=[O:77])[CH2:71][CH2:70]2)[CH2:54]1)(=[O:52])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1