Hydrochloric Acid → 2-Amino-1,1-dimethylethyl acetate hydrochloride

HRID 1601966Notes

Reaction equation

HRID 1601966 reaction equation
[C:1]([O:4][C:5]([CH3:16])([CH3:15])[CH2:6][NH:7]C(OC(C)(C)C)=O)(=[O:3])[CH3:2].[ClH:17]>C(OCC)(=O)C>[ClH:17].[C:1]([O:4][C:5]([CH3:16])([CH3:15])[CH2:6][NH2:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 208271532-(Tert-butoxycarbonylamino)-1,1-dimethylethyl acetate

Product 1

HCID 865873402-Amino-1,1-dimethylethyl acetate hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

2-(tert-Butoxycarbonylamino)-1,1-dimethylethyl acetate (508 mg, 2.2 mmol) was dissolved in ethyl acetate (6 ml). 3 M hydrogen chloride in ethyl acetate (4 ml, 12 mmol) was added. The reaction mixture was stirred for 20 h at room temperature. The precipitation was filtered off and washed with diethyl ether (50 ml). It was dried in vacuo to give 246 mg of 2-amino-I,1-dimethylethyl acetate hydrochloride.

Workup

  1. customThe precipitation
  2. filtrationwas filtered off
  3. washwashed with diethyl ether (50 ml)
  4. customIt was dried in vacuo

Sources & evidence

ORD record
ord-8ae29929e6d349239b666aefe2a4e73d
Source dataset
uspto-grants-1999_11
Patent number
US05977178

Reaction notes

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