Hydrochloric Acid → HCID 15869768, compound

HRID 1602074Notes

Reaction equation

HRID 1602074 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([N:14](C(OC)=O)[C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=3[Cl:25])=[N:12][N:11]=[N:10]2)=[CH:5][CH:4]=1.[OH-].[K+].Cl>CO>[F:31][C:2]([F:1])([F:30])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([NH:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][C:16]=3[Cl:25])=[N:12][N:11]=[N:10]2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19609788HCID 19609788, compound

Product 1

HCID 15869768HCID 15869768, compoundYield 95.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixed solution of 1-(4-trifluoromethylphenyl)-5-(2-chloro-4-trifluoromethyl-N-methoxycarbonyl-anilino)tetrazole (1.2 g), methanol (15 ml) and potassium hydroxide (0.4 g) was stirred at room temperature for 3 hours. After the completion of the reaction, hydrochloric acid (5%; 80 ml) was added thereto. The precipitated crystals were collected by filtration and washed with water to obtain 1-(4-trifluoromethylphenyl)-5-(2-chloro-4-trifluoromethylanilino)tetrazole (1.0 g).

Workup

  1. additionwas added
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-53066d33f9634520adf4101f1bf1872a
Source dataset
uspto-grants-1999_11
Patent number
US05981438

Reaction notes

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