Triethylamine → HCID 19609810, compound

HRID 1602077Notes

Reaction equation

HRID 1602077 reaction equation
[Cl:1][C:2]1[C:11]([CH:12]2[C:17](=O)[CH2:16][CH2:15][CH2:14][C:13]2=[O:19])=[CH:10][C:9]([CH3:20])=[C:8]2[C:3]=1[CH:4]([O:23][CH:24]([CH3:26])[CH3:25])[CH2:5][CH2:6][S:7]2(=[O:22])=[O:21].C(N(CC)CC)C>ClCCCl>[Cl:1][C:2]1[C:11]([C:12]2[C:13](=[O:19])[CH2:14][CH2:15][CH2:16][CH:17]=2)=[CH:10][C:9]([CH3:20])=[C:8]2[C:3]=1[CH:4]([O:23][CH:24]([CH3:26])[CH3:25])[CH2:5][CH2:6][S:7]2(=[O:22])=[O:21]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 19609809HCID 19609809, compound

Product 1

HCID 19609810HCID 19609810, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

0.5 Gram of 5-chloro-8-methyl-6(1,3-dioxocyclohexan-2-yl)-4-(2-propoxy)thiochroman-1,1-dioxide (Compound No. 15 in Table 38) prepared in Preparation Example 6 was dissolved in 5 ml of 1,2-dichloroethane, and 0.12 g of triethylamine was added. The mixture was stirred at room temperature for 1 hour. A formed crystal was recovered by filtration to give, as an end product, 0.3 g of Compound No. 251 shown in Table 48 (yield 65%). Table 60 shows the physical property date of the obtained compound.

Workup

  1. filtrationA formed crystal was recovered by filtration

Sources & evidence

ORD record
ord-da48c0ae4e8c4fa291b56813162c67ee
Source dataset
uspto-grants-1999_11
Patent number
US05981439

Reaction notes

Loading…