HCID 178479206, compound → Ammonia

HRID 1602221Notes

Reaction equation

HRID 1602221 reaction equation
[ClH:1].[NH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]2[N:18]=[CH:17][N:16]=[C:15]3[NH:19][N:20]=[C:21]([NH:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:14]=23)=[CH:8][CH:7]=1>[Ni].CO.C(O)C>[C:3]([CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([NH:12][C:13]2[N:18]=[CH:17][N:16]=[C:15]3[NH:19][N:20]=[C:21]([NH:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:14]=23)=[CH:10][CH:11]=1)#[N:2].[NH3:2].[ClH:1]

Participants

7

Reactant 1

HCID 178479206HCID 178479206, compound

Product 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 178510920HCID 178510920, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

There is obtained from 4-(4-[2-cyano-ethyl]-phenylamino)-3-phenylamino-1H-pyrazolo[3,4-d]pyrimidine (see Example 7), by reduction with Raney nickel in a solution of ammonia in methanol and subsequent treatment with hydrogen chloride in ethanol, 4-(4-[3-amino-propyl]-phenylamino)-3-phenylamino-1H-pyrazolo[3,4-d]pyrimidine hydrochloride.

Sources & evidence

ORD record
ord-f304ea0f9de24fed82e15c28777643ab
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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