HCID 54171516, compound → HCID 54511393, compound

HRID 1602424Notes

Reaction equation

HRID 1602424 reaction equation
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][CH2:13][NH:14][C:15]([CH:17]2[CH2:19][CH2:18]2)=[O:16])[CH:8]=[CH:9][CH:10]=1)[C:2]#[CH:3]>C(N(CC)C1C=CC=CC=1)C>[O:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][CH2:13][NH:14][C:15]([CH:17]3[CH2:19][CH2:18]3)=[O:16])[CH:6]=2)[CH:3]=[CH:2][CH2:1]1

Participants

3

Reactant 1

HCID 54171516HCID 54171516, compound

Product 1

HCID 54511393HCID 54511393, compoundYield 3.9%

Reagents, catalysts & solvents 1

HCID 7061N,N-DiethylanilineSolvent

Procedure

A solution of cyclopropanecarboxylic acid [3-(3-prop-2-ynyloxy-phenyl)-propyl]-amide (415 mg) in N,N-diethylaniline (2 ml) was heated at 215° C. for 24 h. The cooled mixture was purified by column chromatography on silica. Elution with hexane/ethyl acetate 3:1 gave the title compound (A) as a colourless solid (16 mg)

Workup

  1. customThe cooled mixture was purified by column chromatography on silica
  2. washElution with hexane/ethyl acetate 3:1

Sources & evidence

ORD record
ord-9912b5983d794e3288a205879f79c1f1
Source dataset
uspto-grants-1999_11
Patent number
US05981572

Reaction notes

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