HCID 53924084, compound → HCID 44214326, compound

HRID 1602425Notes

Reaction equation

HRID 1602425 reaction equation
[O:1]1[C:10]2[C:5](=[C:6]([CH2:11][CH2:12][CH2:13][NH:14][C:15]([CH:17]3[CH2:19][CH2:18]3)=[O:16])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH2:2]1>C(O)C.[Pt]>[O:1]1[C:10]2[C:5](=[C:6]([CH2:11][CH2:12][CH2:13][NH:14][C:15]([CH:17]3[CH2:18][CH2:19]3)=[O:16])[CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 53924084HCID 53924084, compound

Product 1

HCID 44214326HCID 44214326, compoundYield 73.1%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 702EthanolSolvent

Procedure

A solution of cyclopropanecarboxylic acid [3-(2H-chromen-5-yl)-propyl]-amide (76 mg) in ethanol (5 ml) was hydrogenated over platinum (5% on carbon, 10 mg) for 16 h. The catalyst was filtered off and the filtrate evaporated. The residue was purified by column chromatography on silica. Elution with hexane/ethyl acetate 2:1 gave the title compound as a colourless solid (56 mg)

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated
  3. customThe residue was purified by column chromatography on silica
  4. washElution with hexane/ethyl acetate 2:1

Sources & evidence

ORD record
ord-9c070c2c090f4f2c824667b652ebb020
Source dataset
uspto-grants-1999_11
Patent number
US05981572

Reaction notes

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