Sulfuric Acid → HCID 15858319, compound

A mixture of (-)-(trans)-2-(2,3-dihydrobenzofuran-4-yl)cyclopropanecarboxaldehyde (1.98 g, 10.5 mmol), hydroxylamine hydrochloride (2.29 g, 33 mmol), and 30% NaOH (3.5 mL, 35 mmol), in 5:1 ethanol/water (50 mL) was heated on a steam bath for 2 h. The solution was concentrated in vacuo, and the residue mixed with water. The mixture was extracted with CH2Cl2. The organic extracts were dried and concentrated in vacuo to give a solid which NMR analysis showed to be a mixture of the cis and trans oximes. This material was dissolved in THF (20 mL) and added to solution of alane in THF [prepared from LAH (1.14 g, 30 mmol) and H2SO4 (1.47 g, 15 mmol) at 0° C⟧ The reaction was stirred for 18 h, and quenched successively with water (1.15 mL), 15% NaOH (1.15 mL), and then water (3.45 mL). The mixture was filtered and the filtrate was concentrated in vacuo. The residue was mixed with ether and washed with water and then 1N HCl. The acid washes were made basic and extracted with CH2Cl2. The extracts were dried and concentrated in vacuo to give the amine product (1.4 g, 70.5%). The amine was converted to the fumarate salt in ethanol (mp: 197-198° C.).

1. concentrationThe solution was concentrated in vacuo
2. additionthe residue mixed with water
3. extractionThe mixture was extracted with CH2Cl2
4. customThe organic extracts were dried
5. concentrationconcentrated in vacuo
6. customto give a solid which NMR analysis
7. customquenched successively with water (1.15 mL), 15% NaOH (1.15 mL)
8. filtrationThe mixture was filtered
9. concentrationthe filtrate was concentrated in vacuo
10. additionThe residue was mixed with ether
11. washwashed with water
12. extractionextracted with CH2Cl2
13. customThe extracts were dried
14. concentrationconcentrated in vacuo

ORD record

ord-418fdf81a93e406385448725e1f8f69a

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05981571