Lithium Hydroxide → HCID 78947534, compound

HRID 1602625Notes

Reaction equation

HRID 1602625 reaction equation
C([O:3][C:4](=[O:17])[CH2:5][C@@H:6]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[NH:7][C:8](=[O:10])[CH3:9])C.[Li+].[OH-]>C1COCC1.O>[C:8]([NH:7][C@H:6]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:5][C:4]([OH:17])=[O:3])(=[O:10])[CH3:9]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 86754781HCID 86754781, compound

Product 1

HCID 78947534HCID 78947534, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-14 (0.049 g, 0.102 mmol) in THF (1 mL) and water (0.3 mL) at 0° C. was added 1M LiOH (0.112 ml, 0.112 mmol). After warming to ambient temperature and stirring for 2 h, the solvents were evaporated and the residue was chromatographed (silica gel, 25:10:1:1 ethyl acetate/EtOH/water/NH4OH to give 3-15 as a colorless foam.

Workup

  1. customthe solvents were evaporated
  2. customthe residue was chromatographed (silica gel, 25:10:1:1 ethyl acetate/EtOH/water/NH4OH

Sources & evidence

ORD record
ord-1bc5d28c69b74283a2bd04b9bd18859a
Source dataset
uspto-grants-1999_11
Patent number
US05981546

Reaction notes

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