Hydrochloric Acid → HCID 86754788, compound

HRID 1602654Notes

Reaction equation

HRID 1602654 reaction equation
[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C@@H:6]([C:26]#[CH:27])[N:7]([N:11]1[C@H:15]([CH3:16])[CH2:14][C@H:13]([NH:17]C(OC(C)(C)C)=O)[C:12]1=[O:25])[C:8](=[O:10])[CH3:9])[CH3:2].[ClH:29]>CCOC(C)=O>[ClH:29].[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C@@H:6]([C:26]#[CH:27])[N:7]([N:11]1[C@H:15]([CH3:16])[CH2:14][C@H:13]([NH2:17])[C:12]1=[O:25])[C:8](=[O:10])[CH3:9])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86754787HCID 86754787, compound

Product 1

HCID 86754788HCID 86754788, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 13-10 (550 mg, 1.39 mmol) in EtOAc at 0° C. was bubbled HCl gas for 5 minutes. The reaction was stirred an additional 5 minutes, followed by removal of the cooling bath and then purged with Argon for 20 minutes. Evaporative removal of the solvent gave 13-11 as a white solid.

Workup

  1. customfollowed by removal of the cooling bath
  2. custompurged with Argon for 20 minutes
  3. customEvaporative removal of the solvent

Sources & evidence

ORD record
ord-16dbd0ea81c44248bb17973b8c2d7e7e
Source dataset
uspto-grants-1999_11
Patent number
US05981546

Reaction notes

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