Methanol → HCID 53685075, compound

HRID 1602706Notes

Reaction equation

HRID 1602706 reaction equation
C[O-].[Na+].CO.[C:6]12([C:16]3[CH:36]=[CH:35][C:19]([C:20]([CH2:22][O:23][C:24]4[CH:25]=[C:26]([CH:31]=[CH:32][C:33]=4[I:34])[C:27]([O:29][CH3:30])=[O:28])=O)=[CH:18][C:17]=3[O:37][CH3:38])[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:14][CH:8]([CH2:9]3)[CH2:7]1)[CH2:13]2.[Br-].[CH3:40]P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C1COCC1>[I:34][C:33]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][C:24]=1[O:23][CH:22]=[C:20]([C:19]1[CH:35]=[CH:36][C:16]([C:6]23[CH2:13][CH:12]4[CH2:14][CH:8]([CH2:9][CH:10]([CH2:11]4)[CH2:15]2)[CH2:7]3)=[C:17]([O:37][CH3:38])[CH:18]=1)[CH3:40]

Participants

6

Reactant 4

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 19612291HCID 19612291, compoundHCID 178503020HCID 178503020, compound

Product 1

HCID 53685075HCID 53685075, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 30% sodium methoxide in methanol (0.3 ml, 1.6 mmol) is added over 8 hours to a mixture of methyl 3-[4-(1-adamantyl)-3-methoxybenzoylmethyloxy]-4-iodobenzoate (870 mg, 1.55 mmol) and methyltriphenylphosphine bromide (790 mg, 2.21 mmol) in THF (10 ml).

Sources & evidence

ORD record
ord-f48dfdf38f1a4ade8c6d7d8163dba406
Source dataset
uspto-grants-1999_11
Patent number
US05981776

Reaction notes

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