Trifluoroacetic acid → HCID 131719934, compound

HRID 1602728Notes

Reaction equation

HRID 1602728 reaction equation
[C:1]([C:3]1[CH:20]=[CH:19][C:6]([C:7]([NH:9][N:10](C)[C:11](OC(C)(C)C)=O)=[O:8])=[CH:5][CH:4]=1)#[N:2].C1(OC)C=CC=CC=1.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>ClCCl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][NH:10][CH3:11])=[O:8])=[CH:19][CH:20]=1)#[N:2]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 196104901,1-Dimethylethyl 2-(4-cyanobenzoyl)-1-methylhydrazinecarboxylate

Product 1

HCID 131719934HCID 131719934, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner to Example 14, starting material step (b), the product of step (a) (2.2 g), anisole (2 ml), dichloromethane (20 ml) and TFA (27 ml) were reacted to give N-(4-cyanobenzoyl)-N'-methylhydrazine, trifluoroacetate salt (2.3 g), as a white solid: m.p. 131-134° C.; NMR Spectrum (DMSO-d6) 2.76 (3H, s), 8.00 (4H, s).

Sources & evidence

ORD record
ord-3d44033c55134ec9afe382cda72700ae
Source dataset
uspto-grants-1999_11
Patent number
US05981531

Reaction notes

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