反应详情

50 ml of a 2M aqueous solution of sodium carbonate is added to a solution containing 12 g of 2-bromo 5-nitro anisole, 8.2 g of phenylboronic acid and 1.2 g of tetra(triphenylphosphine) palladium. The whole is heated under reflux for 7 hours, under vigorous agitation. The reaction medium is left to return to 20° C., it is poured into water and extraction is carried out with ethyl acetate. The organic phases are collected, dried and evaporated under reduced pressure. The product obtained is chromatographed on silica, eluting with a heptane-isopropyl ether mixture (9-1) and in this way 11.4 g of sought product is obtained, melting at 71° C.

1. temperatureThe whole is heated
2. temperatureunder reflux for 7 hours, under vigorous agitation
3. waitThe reaction medium is left
4. customto return to 20° C.
5. customThe organic phases are collected
6. customdried
7. customevaporated under reduced pressure
8. customThe product obtained
9. customis chromatographed on silica
10. washeluting with a heptane-isopropyl ether mixture (9-1) and in this way 11.4 g of sought product
11. customis obtained