Hydrochloric Acid → Donepezil Hydrochloride

HRID 1602839Notes

Reaction equation

HRID 1602839 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH2:18][CH2:17]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[CH2:14][CH:13]([CH2:15][CH:16]3[CH2:17][CH2:18][N:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:21]3)[C:11](=[O:12])[C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3152Donepezil

Product 1

HCID 5741Donepezil Hydrochloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

2.0 g of Donepezil was dissolved in 30 ml of toluene at 20° C. Hydrogen chloride gas was blown hereinto at room temperature, until the atmosphere turns acidic. Argon gas was blown hereinto. After stirring for 30 minutes, filtration of the separated crystals followed by drying afforded 2.21 g of the title compound. (water content: 0.65%)

Workup

  1. customwas blown hereinto at room temperature, until the atmosphere
  2. filtrationfiltration of the separated crystals
  3. customby drying

Sources & evidence

ORD record
ord-59bd5105d565402fa7dcc4d3844e14cc
Source dataset
uspto-grants-1999_11
Patent number
US05985864

Reaction notes

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