Potassium Carbonate → HCID 19608484, compound

HRID 1602942Notes

Reaction equation

HRID 1602942 reaction equation
[CH2:1]([C:5]1[N:6]=[N:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:2][CH2:3][CH3:4].Br[CH2:17][C:18]1[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:17][C:18]2[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 869964-(Bromomethyl)benzonitrileHCID 178441902HCID 178441902, compound

Product 1

HCID 19608484HCID 19608484, compoundYield 72.2%

Procedure

Using the procedure of Example 1, 406 mg of the product of Step B and 430 mg of 4-bromomethyl benzonitrile and 830 mg of potassium carbonate were reacted to obtain after chromatography on silica (eluant: methylene chloride-methanol (98-2)), 460 mg of the desired product melting at 180° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9c147537b25b4d7b9e3eadbdd0b13d0a
Source dataset
uspto-grants-1999_11
Patent number
US05985894

Reaction notes

Loading…