Triphenylphosphine → HCID 19608762, compound

HRID 1603002Notes

Reaction equation

HRID 1603002 reaction equation
[Br:1][CH:2]1[CH2:6][CH2:5][N:4]([CH3:7])[C:3]1=[O:8].[C:9]1([P:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1COCC1>[Br-:1].[CH3:7][N:4]1[CH2:5][CH2:6][CH:2]([P+:15]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:3]1=[O:8]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 111829543-Bromo-1-methylpyrrolidin-2-one

Product 1

HCID 19608762HCID 19608762, compoundYield 26.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of (±)3-bromo-1-methyl-2-pyrrolidone (1.40 g, 7.86 mmol) and triphenylphosphine (2 g, 7.62 mmol) in THF (50 ml) was refluxed for 2 days. After cooling to RT the white solid formed was filtered, washed thoroughly with THF and dried to give pure title compound (900 mg, 2.04 mmol, yield 26.8%).

Workup

  1. customformed
  2. filtrationwas filtered
  3. washwashed thoroughly with THF
  4. customdried

Sources & evidence

ORD record
ord-50ce969652834300961d468ab883516c
Source dataset
uspto-grants-1999_11
Patent number
US05985905

Reaction notes

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