Trifluoroacetic anhydride → HCID 19609113, compound

HRID 1603210Notes

Reaction equation

HRID 1603210 reaction equation
[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([S:22](C)=O)[N:14]=[C:13]2[CH2:25][CH2:26][CH3:27])=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.FC(F)(F)C(OC(=O)C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([SH:22])[N:14]=[C:13]2[CH2:25][CH2:26][CH3:27])=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 19609114HCID 19609114, compound

Product 1

HCID 19609113HCID 19609113, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

800 mg of the product obtained in Stage 5 above is introduced into 16 ml of methylene chloride and 0.54 ml of trifluoroacetic anhydride is added. Agitation is carried out for 30 minutes, followed by evaporation to dryness and the residue is taken up in 10 ml of methanol and 4 ml of triethylamine. After agitation for 30 minutes, extraction is carried out with chloroform, the extracts are washed with a saturated solution of ammonium chloride, dried and evaporated to dryness. In this way 720 mg of expected product is obtained.

Workup

  1. additionis added
  2. customfollowed by evaporation to dryness
  3. waitAfter agitation for 30 minutes
  4. extractionextraction
  5. washthe extracts are washed with a saturated solution of ammonium chloride
  6. customdried
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-f35faa68d18d462d9124a75eab82c200
Source dataset
uspto-grants-1999_11
Patent number
US05986103

Reaction notes

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