5-[2-(2,5-Dimethoxyphenyl)ethenyl]-2-acetylamino benzoic acid methylester → HCID 54506424, compound

HRID 1603526Notes

Reaction equation

HRID 1603526 reaction equation
[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[C:8]([CH:10]=[CH:11][C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[O:20][CH3:21])[CH:7]=[CH:6][C:5]=1[NH:22][C:23](=[O:25])[CH3:24]>C(OCC)(=O)C.[Pd]>[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[C:8]([CH2:10][CH2:11][C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[O:20][CH3:21])[CH:7]=[CH:6][C:5]=1[NH:22][C:23](=[O:25])[CH3:24]

Participants

4

Reactant 1

HCID 543195135-[2-(2,5-Dimethoxyphenyl)ethenyl]-2-acetylamino benzoic acid methylester

Product 1

HCID 54506424HCID 54506424, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

150 mg of 5-[2-(2,5-dimethoxyphenyl)ethenyl]-2-acetylamino benzoic acid methylester are dissolved in 10 ml of ethyl acetate. After addition of 25 mg of palladium (10% on charcoal) the mixture is stirred overnight under an atmosphere of hydrogen and filtered over celite. The filtrate is evaporated in vacuo to obtain the title compound as colourless crystals. mp:81-83°.

Workup

  1. filtrationfiltered over celite
  2. customThe filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-e04b782641e346d696ddb461e4e59762
Source dataset
uspto-grants-1999_11
Patent number
US05990116

Reaction notes

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