Tolylboronic acid → HCID 19605483, compound

HRID 1603580Notes

Reaction equation

HRID 1603580 reaction equation
Br[C:2]1[CH:7]=[C:6]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])[CH:5]=[C:4]([N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[N:3]=1.[C:23]1([CH3:32])[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl>[N:18]1([C:4]2[CH:5]=[C:6]([S:8]([C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=3)(=[O:10])=[O:9])[CH:7]=[C:2]([C:26]3[CH:27]=[CH:28][C:23]([CH3:32])=[CH:24][CH:25]=3)[N:3]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

6

Reactant 2

HCID 79799Tolylboronic acidHCID 69186894-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine

Product 1

HCID 19605483HCID 19605483, compoundYield 40.7%

Reagents, catalysts & solvents 3

HCID 6102075Dichlorobis(triphenylphosphine)palladiumCatalystHCID 1140TolueneSolventHCID 11430Potassium CarbonateSolvent

Procedure

A mixture of 191 mg (0.5 mmole) 4-(2-bromo-6-pyrrolidine-1-yl-pyridine-4-sulfonyl)-phenylamine, 84 mg (0.55 mmole) 4-tolylboronic acid, 18 mg bis(triphenylphosphine)-palladium(II)-chloride is refluxed for 2.5 hours in 7 ml toluene and 2 ml 2N aqueous potassium carbonate. The solvents are removed in vacuo. Flash chromatography (silicagel, ethyl acetate/hexane 1/1) of the residue yields 80 mg (40%) pure 4-(2-pyrrolidine-1-yl-6-p-tolyl-pyridine-4-sulfonyl)-phenylamine as a pale yellow solid mp.: 250-251° C.

Workup

  1. customThe solvents are removed in vacuo

Sources & evidence

ORD record
ord-b548ad9c61c74302b741ad0911c092e7
Source dataset
uspto-grants-1999_11
Patent number
US05990105

Reaction notes

Loading…