Chloroacetyl chloride → HCID 4778525, compound

HRID 1603719Notes

Reaction equation

HRID 1603719 reaction equation
[ClH:1].Cl[C:3]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]2[C:4]=1[C:5]([OH:26])=[C:6](SC1C=CC(NC(=N)C)=CC=1)[C:7](=[O:14])[NH:8]2.ClC[C:29](Cl)=[O:30].C(N(CC)CC)C>CO>[CH3:29][O:30][C:5](=[O:26])[C:4]1[CH:3]=[CH:12][C:11]([Cl:13])=[CH:10][C:9]=1[NH:8][C:7](=[O:14])[CH2:6][Cl:1]

Participants

5

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 178465579HCID 178465579, compound

Product 1

HCID 4778525HCID 4778525, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The intermediate 7 was prepared by the same procedure for the intermediate 6, using a intermediate 5 (2.7 g, 14.6 mmol), chloroacetyl chloride (2.37 mL, 30.0 mmol) and triethylamine. After normal workup, the pure title compound was obtained by recrystallization from MeOH as a white solid (3.44 g, 90%):

Sources & evidence

ORD record
ord-6fb9d4a073be406da905d879f9d51de7
Source dataset
uspto-grants-1999_11
Patent number
US05990126

Reaction notes

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