反应详情

4-Methyl-3-(pyrid-3-yl) aniline (0.30 g, 0.0016 mole) in dry dichloromethane (20 ml) was added, under argon, to 1,1'-carbonyldiimidazole in dry dichloromethane (10 ml) (0.30 g, 0.0018 mole) and stirred at ambient temperature for 1 hour. The solvent was removed in vacuo and the residue dissolved in dry dimethylformamide (30 ml). 6-Chloro-5-methylindoline (see WO 95/01976) (0.27 g, 0.0016 mole) in dry dimethylformamide (10 ml) was added and the mixture heated to 100° C. for 1 hour. After cooling to ambient temperature, the solvent was removed in vacuo and the residue diluted with deionised water (15 ml), extracted into dichloromethane (2×20 ml), dried (Na2SO4) and evaporated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with 3% methanol/dichloromethane and the resulting solid recrystallised from ethyl acetate/methanol/60-80° petroleum ether to afford the title compound (0.31 g, 57%) as a cream solid (mp 202-203° C.).

1. customThe solvent was removed in vacuo
2. dissolutionthe residue dissolved in dry dimethylformamide (30 ml)
3. temperaturethe mixture heated to 100° C. for 1 hour
4. temperatureAfter cooling to ambient temperature
5. customthe solvent was removed in vacuo
6. additionthe residue diluted with deionised water (15 ml)
7. extractionextracted into dichloromethane (2×20 ml)
8. dry with materialdried (Na2SO4)
9. customevaporated in vacuo
10. customThe residue was purified by flash column chromatography on silica gel
11. washeluting with 3% methanol/dichloromethane
12. customthe resulting solid recrystallised from ethyl acetate/methanol/60-80° petroleum ether