Hydrogen Bromide → HCID 22004117, compound

HRID 1603847Notes

Reaction equation

HRID 1603847 reaction equation
[ClH:1].C[O:3][C:4]1[C:12]2[N:11]=[CH:10][N:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:8]=2[CH:7]=[CH:6][CH:5]=1.Br>C(O)(=O)C>[ClH:1].[OH:3][C:4]1[C:12]2[N:11]=[CH:10][N:9]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:8]=2[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 70247570HCID 70247570, compound

Product 1

HCID 22004117HCID 22004117, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Demethylation of 4-methoxy-1-phenylbenzimidazole hydrochloride with HBr in glacial acetic acid as described for synthesis of Example 2 gave Example 11 as the HCl salt, (77%): mp (MeOH/Et2O) 238-240° C.

Sources & evidence

ORD record
ord-db31e96638a44264a84d9ff9b645a95e
Source dataset
uspto-grants-1999_11
Patent number
US05990146

Reaction notes

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