4-Bromophenol → Phenol, 4-bromo-, 1-acetate

HRID 1603874Notes

Reaction equation

HRID 1603874 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](OC(=O)C)(=[O:18])[CH3:17]>C(Cl)(Cl)Cl>[C:16]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:18])[CH3:17]

Participants

5

Reactant 3

HCID 78084-BromophenolHCID 7918Acetic AnhydrideHCID 8471Triethylamine

Product 1

HCID 74726Phenol, 4-bromo-, 1-acetate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 4-bromophenol (25 g, 0.145 mol) in 100 ml of chloroform was added at 0° C. with triethylamine (20.1 ml) and acetic anhydride (16.4 ml) stirring at room temperature for 2 h. After that the mixture was washed with a 0.2M HCl solution, dried and the solvent was evaporated off under reduced pressure, thereby obtaining the title compound as a colourless oil (quantitative yield).

Workup

  1. washAfter that the mixture was washed with a 0.2M HCl solution
  2. customdried
  3. customthe solvent was evaporated off under reduced pressure

Sources & evidence

ORD record
ord-a79db426f9a84c41879f67e58dc8c8d3
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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