HRID1603907

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7268

Diethyl oxalate

C6H10O4

结构：CC(=O)c1cc(F)cc(NC(=O)c2ccc3c(c2)CC(CCCc2ccccc2)O3)c1O

HCID19606348

未命名化合物

PRODUCTS

生成物

HCID702

Ethanol

C2H6O

收率 55%

结构：CCOC(=O)c1cc(=O)c2cc(F)cc(NC(=O)c3ccc4c(c3)CC(CCCc3ccccc3)O4)c2o1

HCID19606340

未命名化合物

PROCEDURE

实验过程

Following the process described in example 1 (point A), starting from N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-2-(3-phenylpropyl)-2,3-dihydrobenzofuran-5-carboxamide and diethyl oxalate, the title compound was prepared, which was purified by crystallization in ethanol (55% yield).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd9c194321024850889bdedc284aaa01
来源数据集: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05990142
来源说明: uspto-grants-1999_11

反应 SMILES

[C:1]([C:4]1[C:5]([OH:32])=[C:6]([NH:11][C:12]([C:14]2[CH:15]=[CH:16][C:17]3[O:21][CH:20]([CH2:22][CH2:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[CH2:19][C:18]=3[CH:31]=2)=[O:13])[CH:7]=[C:8]([F:10])[CH:9]=1)(=[O:3])[CH3:2].[C:33](OCC)(=O)[C:34]([O:36][CH2:37][CH3:38])=[O:35]>>[C:25]1([CH2:24][CH2:23][CH2:22][CH:20]2[CH2:19][C:18]3[CH:31]=[C:14]([C:12]([NH:11][C:6]4[C:5]5[O:32][C:33]([C:34]([O:36][CH2:37][CH3:38])=[O:35])=[CH:2][C:1](=[O:3])[C:4]=5[CH:9]=[C:8]([F:10])[CH:7]=4)=[O:13])[CH:15]=[CH:16][C:17]=3[O:21]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[CH2:1]([OH:3])[CH3:2]